Matrix Metalloproteinase and Tissue Inhibitor Expression in Atherosclerotic and Non-Atherosclerotic Thoracic Aortic Aneurysm

Expression in Atherosclerotic Lesions of Hypercholesterolemic Rabbits The ACAT Inhibitor Avasimibe Reduces Macrophages and Matrix Metalloproteinase

Given the significance of cholesteryl ester (CE) accumulation in macrophage foam cell formation, we hypothesized that inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) would produce a histologically stable lesion by limiting macrophage enrichment and thereby a source of matrix metalloproteinases (MMPs). Male New Zealand White rabbits were sequentially fed a cholesterol/fat diet for 9 ...

The ACAT inhibitor avasimibe reduces macrophages and matrix metalloproteinase expression in atherosclerotic lesions of hypercholesterolemic rabbits.

Given the significance of cholesteryl ester (CE) accumulation in macrophage foam cell formation, we hypothesized that inhibitors of acyl-CoA:cholesterol O-acyltransferase (ACAT) would produce a histologically stable lesion by limiting macrophage enrichment and thereby a source of matrix metalloproteinases (MMPs). Male New Zealand White rabbits were sequentially fed a cholesterol/fat diet for 9 ...

Inflammation and Non-Atherosclerotic Coronary Artery Aneurysm

@Copyright 2014 by Koşuyolu Heart Journal Available on-line at www.kosuyolukalpdergisi.com E-mail: [email protected] Submitted : 03.11.2013 Accepted : 30.11.2013 Mete Gürsoy Correspondence Introduction: Coronary artery aneurysm is generally presented as an asymptomatic, incidental angiographic finding and is often associated with atherosclerosis. In this study we investigated the relation ...

Expression of Matrix Metalloproteinase-2/9 and Tissue Inhibitor of Metalloproteinase-1/2 as Predictive Factors in Oropharyngeal Squamous Cell Carcinoma

Introduction: Metalloproteinases and their tissue inhibitors play an important role in the metastases formation. A multistage process of carcinogenesis requires the involvement of numerous enzymes and compounds that facilitate the expansion of tumor cells. The formation of metastases depends on both metalloproteinases and tissue inhibitors activation leading to the acti...

Section 5. Atherosclerotic Peripheral Vascular Disease and Aortic Aneurysm